Warfarin Institute of America

DEDICATED TO YOUR HEALTH SINCE 2000

Angelica pubescens (Du Huo) INTERACTION WITH WARFARIN
  Angelica pubescens is used to treat arthritis, lumbago, edema, headache, thrombosis and stasis of blood. It contains osthole, which was found to inhibit platelet aggregation and thromboxane formation in rabbit platelets; it was also found to suppress phosphoinositide breakdown. Thromboxane A2 is instrumental in platelet aggregation. Phosphoinositide breakdown provides necessary free arachadonate for thromboxane A2 synthesis. Because of these mechanisms, concurrent intake with warfarin (Coumadin, Jantoven) may result in increased risk of bleeding.

Reference:

Ko FN, Wu, TS, Liou MJ, Huang TF, Teng CM.Inhibition of platelet thromboxane formation and phosphoinositides breakdown by osthole from Angelica pubescens. Thrombosis and Haemostasis 1989; 62:996-999.

An editorial about the lack of concern for manufacturers of these products and their interactions with other medications.

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© 2001 Patricia Chuong

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Last updated June 14, 2007