Warfarin Institute of America
DEDICATED TO YOUR HEALTH SINCE 2000
I was vacationing when sadly I developed a toothache. The pain became intolerable while taking 400mg Ibuprofen quite regularly so I took a couple Oxycontin. This morning my INR was 4.7. Could either of these drugs caused the jump? - Smitty
No, neither oxycontin nor ibuprofen effect the blood levels of warfarin. Ibuprofen does however affect your body’s ability to clot. This is because ibuprofen causes the platelets in your blood to decrease in “stickiness.” They are less apt to stick together or to your blood vessels, but this effect wears off after several hours. This is a totally different mechanism from the way warfarin works, so it does not affect INR.
References:
Catella-Lawson F, Reilly M, KApoor S, Cucchiara A, et al. Cyclooxygenase inhibitors and the antiplatelet effects of aspirin. The New England Journal of Medicine 2001; Vol. 345, Iss. 25; p 1809-1817.
Andrioli G, Lussignoli S, Gaino S, Benoni G, Bellavite P. Study on the paradoxical effects of NSAIDs on platelet activation. Inflammation 1997, Vol. 21, No. 5; p 519-528
©2007 Steven Abraham
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Last updated June 19, 2007
