Warfarin Institute of America
Dedicated To Your Health
PREDNISONE INTERACTION WITH WARFARIN
Brand Names: Meticorten, Orasone, Panasol-S, Deltasone, Prednicen-M, Sterapred DS, Liquid Pred
This is a rather unusual interaction. There are case reports of the INR both increasing and decreasing when prednisone is added to the medications of someone already taking warfarin.
I have seen everything from very large increases in the INR to absolutely nothing happening when prednisone is added to warfarin. It appears that large doses of prednisone have the most effect in raising the INR, but this has not been proven. I saw one patient who was started on prednisone 100 mg/day and told by a doctor at an internationally famous hospital that there would be no interaction with his warfarin. A few days later he was bleeding from the pores of his skin. His INR was higher than we could measure and he had to be admitted to the hospital for warfarin reversal.
If you are taking warfarin and prednisone is prescribed for you, the safest action is to have your INR monitored after about three to five days.
If you are taking both warfarin and prednisone, and the prednisone is stopped, the safest action is to have your INR monitored after three to five days.
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Last updated November 15, 2004