Warfarin Institute of America
DEDICATED TO YOUR HEALTH
THE QUESTION OF THE DAY
I have Antiphospholipid Antibody Syndrome. I take my warfarin regularly but the INR jumps around a lot. I have even had clots when my INR was up around 5. Why? -- L
The surface of the blood vessels is a phospholipid. People ordinarily have antibodies that tell the blood not to clot on this surface because it is "me". In your case you have antibodies to the antibodies so that your blood dose not recognize the walls of the veins and arteries as "me" but treats them as "not me" and clots them off. There is no medication that can change this. The way that warfarin works does not make it a very good drug in this condition. The materials for the PT/INR test use phospholipids too. For the same reason that warfarin does not prevent clots very well in AAS, the PT/INR results do not give a very good picture of what is going on either. The harsh reality is that these are the best we have but they are not very good.
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Last updated January 22, 2006